We use an optical coherence tomography system with a specially designed probe to image the structures of tissues within the oral cavity for the diagnosis of oral precancer and cancer. Classification of human stomach cancer using morphological. Optical coherence tomography oct is one such emerging lightbased diagnostic modality that provides noninvasive, realtime images at a depth of 1. Essentially, this technique employs nearinfrared light waves and computer imaging to.
Optical coherence tomographic imaging was combined with endoscopic photography for gross and histologic image correlation. Optical coherence tomography as an oral cancer screening adjunct in a low resource settings. Risk factors for oral cancer include tobacco use, excessive consumption of alcohol. Intravital microscopy ivm and optical coherency tomography oct are two powerful optical imaging tools that allow visualization of dynamic biological activities in living subjects with subcellular resolutions. Detection of oral pathologies using optical coherence. Introduction tumor detection and visualization plays a key role in the clinical workflow of a patient with suspected cancer, both in the diagnosis and in. Optical coherence tomography in oral cancer pdf uk voice. Optical coherence tomography, a technique previously used to image breast cancer tumor margins intraoperatively in humans and lymphnode microarchitecture in a rat animal model, was being presented for the intraoperative exvivo imaging and assessment of axillary lymph nodes. Optical coherence tomography is based on lowcoherence interferometry, typically. Optical coherence tomography oct is an emerging noninvasive, noncontact technology capable of highresolution imaging of the mucosal epithelium and lamina propria lp. In vivo imaging in the oral cavity by endoscopic optical. Stimulidisassembling gold nanoclusters for diagnosis of. Various lightbased diagnostics are currently available to the clinician for early diagnosis of oral cancer.
Optical coherence tomographyprinciples and applications. We demonstrate the ex vivo imaging of an oral cancerous sample with a sweptsource optical coherence tomography ssoct system. Enhanced detection of earlystage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles. Diagnosis of oral precancer with optical coherence tomography ncbi. Optical coherence tomography as an oral cancer screening adjunct in a low. Plasmonic gold nanoparticles au nps have been developed as contrast agents due to their strong surface plasmon resonance spr.
Lowcost, ultracompact handheld optical coherence tomography probe for in vivo oral maxillofacial tissue imaging kaiyan li, a zihan yang, b wenxuan liang, c jianwei shang, d yanmei liang, b, and suiren wan a, asoutheast university, school of biological science and medical engineering, nanjing, jiangsu, china. The clinician can obtain realtime images of the architecture of the skin without pretreatment or gels. The current gold standard for clinical diagnosis of melanoma is excisional biopsy and histopathologic analysis. Optical coherence tomography oct imaging was evaluated to determine if radiationinduced mucosal damage could be noninvasively monitored in real time and correlated with histopathologic findings. Objective was to investigate in vivo noninvasive optical coherence tomography oct techniques for imaging and diagnos. The background of oct, including basic theory, system setup, light sources, spatial resolution and system limitations, is provided. Oct represents a new highresolution optical technique that permits 3d, realtime imaging of near surface abnormalities in complex. Develop an imaging technique to detect premalignant airway epithelial changes carcinoma in situ, dysplasia to study the transformation process as well as intervene and prevent the development of lung cancer.
Keywords optical coherence tomography cancer tumor imageguided surgery optical imaging. Due to its many technical advantages such as high image resolution, fast acquisition time, and noninvasive capabilities, oct is potentially useful in. Accurate surgical margin demarcation critical for improved outcome in oral cancer. This chapter highlights the advancements in oral cancer exploration using optical coherence tomography oct with a discussion on basic principles of oct, followed by a detailed description of. Institute of physics publishing reports on progress in physics rep. Optical coherence tomography is one of the new emerging technique for imaging oral mucosal tissues. Pdf advances in oral cancer detection using optical. Optical coherence tomography oct is a noninvasive optical imaging technique that uses lowpower infrared laser light to image up to 2 mm beneath the skin surface. Structural validation of oral mucosal tissue using optical. Optical coherence tomography combines light from a low author affiliations.
In vivo optical coherence tomography of the human oral. Optical coherence tomography an overview sciencedirect. Optical imaging of oral squamous cell carcinoma using. Advances in oral cancer detection using optical coherence tomography. Index terms3d image, optical coherence tomography oct, oral cancer detection. Pdf optical coherence tomography oct is a new modality capable of cross sectional imaging of biological tissue. During the lumpectomy, the surgical team may employ optical coherence tomography oct to help achieve the cleanest and most thorough tumor removal. Optical coherence tomography in oral cancer detection. Pdf optical coherence tomography as an oral cancer screening. But, this requires removal of tissue which is again an invasive process.
Intraoperative imaging of oralmaxillofacial lesions using optical. Octs hreh resolution imaging capability is wesuited for detecting speci. To assess noninvasive optical coherence tomography oct and optical doppler tomography odt for early detection and evaluation of chemotherapyinduced oral mucositis. Improving oral cancer outcomes with imaging and artificial. Evaluation of radiationinduced oral mucositis by optical. The comparisons between oct and other clinical oral diagnostic methods are also discussed. Optical coherence tomography oct is a new modality capable of cross sectional imaging of biological tissue. It may evolve from oral mucosal lesions with benign epithelial. Diagnosis of oral precancer with optical coherence tomography. S0034488503187039 optical coherence tomographyprinciples and applications a f fercher 1, w drexler, c k hitzenberger and t lasser2 1 institute of medical physics, university of vienna, waehringer strasse, a1090 wien, austria 2 laboratoire. Histopathological examination is still the gold standard for diagnoses of oralmaxillofacial lesions, but it is invasive and timeconsuming. Home forums uk voice forum optical coherence tomography in oral cancer pdf tagged. That is because of the vacancy of technologies capable to perform images with. Squamous cell carcinoma scc is the most common cancer in the oral cavity.
Three indicators are considered, including the standard deviation sd of an amode scan signal profile, the exponential decay constant. Mapping of field cancerization by oct precisely detected high grade dysplasia. Pdf optical coherence tomography in oral cancer detection. Pdf enhanced detection of earlystage oral cancer in. A sweptsource optical coherence tomography system is used to clinically scan oral precancer and cancer patients for statistically analyzing the effective indicators of diagnosis.
Article information, pdf download for improving oral cancer. Pdf oral cancer is the sixth most common cancer worldwide, predominantly seen in low and middleincome countries lmic. Also explore the seminar topics paper on optical coherence tomography with abstract or synopsis, documentation on advantages and disadvantages, base paper presentation slides for ieee final year ieee biomedical engineering, biotechnology in btech. Optical coherence tomography in oral cancer detection article pdf available in journal of international dental and medical research 2016. A procedure for computer analyzing an optical coherence tomography oct image of normal and precancerous oral mucosae is demonstrated to reasonably plot the boundary between epithelium ep and lamina propria lp layers, determine the ep thickness, and estimate the range of dysplastic cell distribution based on standard deviation sd mapping. Optical coherence tomography for oral cancer diagnosis. In vivo optical coherence tomography for the diagnosis of oral malignancy, wilder. Optical coherence tomography oct has been proved to be a useful technique for oral disease diagnosis 518. Rao1, shankargouda patil2 1department of oral and maxillofacial pathology, faculty of dental sciences, m s ramaiah university of applied sciences, bengaluru, karnataka, india. Osa effective indicators for diagnosis of oral cancer.
The main techniques currently utilised in the detection of oral dysplasia are fluorescence, raman spectroscopy, microendoscopy, elastic scattering spectroscopy and optical coherence tomography. Optical coherence tomography for oral mucosal lesions. Oral squamous cell carcinoma oscc is the sixth most frequently occurring. The purpose of the present study was to determine normal values of epithelial thickness within the oral cavity by using optical coherence tomography oct.
Optical coherence tomography and microelastography for. Advances in oral cancer detection using optical coherence. In particular, based on the scanning images of a sweptsource oct system, a few effective diagnosis indicators for oral cancer and precancer have been identified 1517. The generated supercontinuum can be used as a light source in an optical coherence tomography oct system to detect oral cancer with a resolution of 964 nm. Pdf oral cancer diagnosis with optical coherence tomography. The clinical usefulness of optical coherence tomography. Our results show that compared to the changes observed in the epithelium thickness and the decay constant of ascan intensity profile, a much larger degree of change was observed in the phase retardation for.
Potential of optical coherence tomography for early diagnosis of oral. Oral squamous cell carcinoma oscc constitutes 90% of oral cancer. Human exvivo oral tissue imaging using spectral domain. Optical coherence tomographic images of the oral cavity and oropharynx provided microanatomical information on the epithelium, basement membrane bm, and supporting lamina propria lp of the mucosa. Fifteen million people worldwide will be diagnosed. Optical coherence tomography is a novel imaging technique providing highresolution. Optical coherence tomography oct is a noninvasive optical technology using nearinfrared light to. Recent advances in labeling and labelfree techniques empower ivm and oct for a wide range of preclinical and clinical cancer imaging, providing profound insights. We report the use of spectral domain polarization sensitive optical coherence tomography for exvivo imaging of human oral mandibular tissue samples.
Optical microscopy and coherence tomography of cancer in. Optical coherence tomography oct provides a kind of noninvasive, labelfree, realtime and highresolution imaging technology. Due to its many technical advantages such as high image resolution, fast acquisition time, and noninvasive capabilities, oct is potentially useful in various. Cheek pouches of 10 syrian golden hamsters were imaged using octodt during development of chemotherapyinduced mucositis. Classification of human stomach cancer using morphological feature analysis from optical coherence tomography images to cite this article. Dr digant p dave oral cancer causes 120000 deaths annually around the world and. Pdf we use an optical coherence tomography system with a specially designed probe to image the structures of tissues within the oral cavity. Research open access structural validation of oral mucosal tissue using optical coherence tomography zaid hamdoon1,2,3,4, waseem jerjes3,5,6, raed aldelayme3, gordon mckenzie4,6, amrita jay4 and colin hopper2,4,5 abstract background. Explore optical coherence tomography with free download of seminar report and ppt in pdf and doc format. Noninvasive diagnostic adjuncts for the evaluation of potentially. Optical coherence tomography oct is a medical noninvasive imaging modality that seems suitable for the task mentioned above at hand, with some preclinical and clinical experience in the. Oct for the diagnosis of multiple stages of oral cancer progression. Optical coherence tomography of oral mucosa publication no. Optical coherence tomography seminar report, ppt, pdf.
Recent citations identification of atherosclerotic plaques in intravascular optical coherence. Approximately 1530 benign lesions are biopsied to diagnose each melanoma. In vivo optical coherence tomography for the diagnosis of oral malignancy. Amany imaging applications,optical coherence tomographocts a fast,va,h res olution imaging modality that uses a mhelsons interferometer with a low coherence light sourc14. This study aims to demonstrate that stimuliresponsive plasmonic au nanoclusters au ncs can be used as a contrast agent for optical coherence tomography oct in detecting earlystage cancer. Potential of optical coherence tomography for early. Oct was equivalent to histology in tumor margin delineation k 0. Kim et al enhanced detection of earlystage oral cancer in vivo by optical coherence tomography journal of biomedical optics 0340082 mayjune 2009 vol. In vivo optical coherence tomography for the diagnosis of. Endoscopic optical coherence tomography system setup.
It is a noninvasive technique which produces crosssectional images of oral mucosal tissues at cellular and subcellular levels. Optical coherence tomography of the airway for lung cancer. The oct system used in this study is spectrometerbased and consists of a fibercoupled superluminescent diode sld371hp1, superlumdiodes ltd. Correlate optical coherence tomography images of the airway with airway histology.
In addition, biopsies are invasive and result in pain, anxiety, scarring, and disfigurement of patients, which can add additional burden to the health care system. Methods in a total of 143 healthy test persons, epithelial thickness of the oral mucosa was determined with the help of oct separately for each side at 7 different locations. Optical radiomic signatures derived from optical coherence. Optical coherence tomography oct is a 3d imaging technique based on lowcoherence interferometry huang et al. Optical coherence tomography oct is an imaging technique that uses lowcoherence light to capture micrometerresolution, two and threedimensional images from within optical scattering media e. Improved lumpectomy margins using optical coherence tomography. Optical coherence tomography oct evaluated for surgicalmargin delineation. Improved highly sensitive diagnostics allowing early detection of oral cancer would benefit patient survival and quality of life. It is used for medical imaging and industrial nondestructive testing ndt. Accounting for 96% of all oral cancers, squamous cell carcinoma scc is usually preceded by dysplasia presenting as white epithelial lesions on the oral mucosa. Female c3h mice, ages 7 to 9 weeks, four per group, were immobilized in a custommade lucite jig and received 0, 15, 22.
Delineation of an oral cancer lesion with sweptsource. These indicators include the ep layer thickness and the. In this study, in order to assess the feasibility of oct in oral clinical application, fresh excised tissue specimens from 59 patients undergoing oralmaxillofacial surgery were imaged in detail by using a benchtop swept. Measurement of epithelial thickness within the oral cavity. Efficacy of optical coherence tomography in the detection of. Intraoperative imaging of oralmaxillofacial lesions using. Enhanced detection of earlystage oral cancer in vivo by. Intraoperative pointofprocedure delineation of oral. Optical coherence tomography as an oral cancer screening.